Detoxification and Immunotropics
Detoxification is a highly essential process that occurs in your body and responsible for your well-being and vitality. It can lead to an adversely worse outcome in the form of early morbidity and mortality in case it is lacking. The process of detoxification involves the mobilization, biotransformation, and elimination of toxins from your body and occurs mainly in the liver. These toxins could be formed both internally as well as externally1.
Liver detoxification has two main pathways or phases that convert toxins from lipophiles (fat-soluble) to hydrophiles (water-soluble) metabolites passing via a series of reactions:
Phase I reduces fat, glucose, carbohydrates, proteins, toxins, pharmaceuticals, absorbed through the digestive tract into intermediary substances. This is mediated by the function of CYP450 enzymes that add a reactive group such as a hydroxyl, carboxyl, or an amino group through oxidation, reduction, and/or hydrolysis reactions.
Phase II converts the intermediates from Phase I into water-soluble waste products that can be eliminated from your body. Conjugation involves the transfer of several water loving compounds such as glucuronic acid, sulfate, glutathione, amino acids, an acetyl group, methyl group to the metabolites to convert them into their water-soluble form to enhance excretion in the bile or urine2,3.
Biavexia – I am Immune drink shot has valuable ingredients that help in the detoxification process of the liver and keep you healthy as discussed below.
Vitamins such as vitamin A, C, E act as antioxidants and cofactors to enzymes in Phase I of the detoxification process. Studies have demonstrated the preventative and therapeutic effects of these vitamins on several liver diseases, including alcoholic and non-alcoholic fatty liver disease, cancer, and viral hepatitis. Methyltransferases are a class of phase II liver enzymes that play a role in methylation with the help of nutrient cofactors. The cofactors include B vitamins such as cobalamin (B12), pyridoxine (B6) and folate (B9)4. Research has found that insufficient methylation is associated with an increased risk of diseases such as heart conditions and anemia5.
Grape seed extract alters the antioxidant enzyme activities in your liver. It increases the detoxification of postprandial xenobiotics and toxins via liver conjugation6. Similarly, catechins in green tea extract act as reactive oxygen species (ROS) scavengers and toxin chelators. The indirect antioxidant activities of the catechins include induction of antioxidant enzymes, and production of the phase II detoxification enzymes. Oxidative stress and ROS are implicated in aging and related dysfunctions, such as neurodegenerative diseases, cancer, cardiovascular diseases and diabetes7.
Glutathione plays a critical role in the reduction of oxidative stress, enhancement of metabolic detoxification and regulation of immune system function. Research has shown that chronic liver diseases are associated with a reduction in glutathione levels. This leads to the hypothesis that increasing glutathione levels can prevent or decrease the progression of these diseases8. Your body requires all three amino acids, glycine, cysteine and glutamic acid and adequate enzymatic function in the liver to make sufficient quantities of glutathione. Cysteine is frequently identified as rate-limiting, which provides the rationale of why N-acetylcysteine (NAC) is often recommended as a supplement for glutathione support. NAC is convincing as a supplement to both boost glutathione levels and potentially reduce some of the issues related to oxidative stress9. Similarly, several clinical trials in diverse populations have indicated that alpha-lipoic acid is highly essential for scavenging free radicals and removing toxins from your body10.
In this way, the Biavexia – I am Immune drink shot provides essential nutrients that are required for the detoxification process in your body. For further details, please consult your health care provider.
- Grant, D.M. Detoxification pathways in the liver. J Inherit Metab Dis14, 421–430 (1991). https://doi.org/10.1007/BF01797915
- Cline JC. Nutritional aspects of detoxification in clinical practice. Altern Ther Health Med. 2015;21(3):54-62.
- Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015; 2015:760689. doi:10.1155/2015/760689.
- Guan YS, He Q. Plants consumption and liver health. Evidence-based complementary and alternative medicine. 2015; 2015:824185. doi:10.1155/2015/824185.
- Strickland KC, Krupenko NI, Krupenko SA. Molecular mechanisms underlying the potentially adverse effects of folate. Clin Chem Lab Med. 2013;51(3):607-616. doi:10.1515/cclm-2012-0561.
- Fernández-Iglesias A, Quesada H, Díaz S, et al. Combination of grape seed proanthocyanidin extract and docosahexaenoic acid-rich oil increases the hepatic detoxification by GST mediated GSH conjugation in a lipidic postprandial state. Food Chem. 2014;165:14-20. doi:10.1016/j.foodchem.2014.05.057.
- Bernatoniene J, Kopustinskiene DM. The Role of Catechins in Cellular Responses to Oxidative Stress. Molecules. 2018;23(4):965. Published 2018 Apr 20. doi:10.3390/molecules23040965
- Minich DM, Brown BI. A Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients. 2019;11(9):2073. doi:10.3390/nu11092073
- Lu SC. Glutathione synthesis. Biochim Biophys Acta. 2013;1830(5):3143-3153. doi:10.1016/j.bbagen.2012.09.008.
- Zhao L, Hu FX. α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction. Eur Rev Med Pharmacol Sci. 2014;18(23):3715-3719.